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  JOURNAL "NP" ISSUES

"Nauchnoe Priborostroenie", 2022, Vol. 32, no. 4. ISSN 2312-2951, DOI: 10.18358/np-32-4-e110

"NP" 2022 year Vol. 32 no. 4.,   ABSTRACTS

ABSTRACTS, REFERENCES

V. E. Kurochkin, S. V. Mjakin, N. A. Bubis, L. M. Kuznetzov, A. Y. Shmykov

REGULATION OF HYDROPHILIC-HYDROPHOBIC PROPERTIES OF SILICON WAFERS

"Nauchnoe priborostroenie", 2022, vol. 32, no. 4, pp. 3—10.
doi: 10.18358/np-32-4-i310
 

The possibility of a wide range of adjustment of hydrophilic-hydrophobic properties of silicon wafers is demonstrated by means of treatment with hydrofluoric acid, Caro's acid, and various concentrations of hydrogen peroxide solutions. By measuring the contact angles of wetting and calculating the total, polar and dispersive components of the surface energy, it has been found that the most significant hydrophilization of the silicon surface as well as the maximum increase in the surface energy is achieved when the surfice is treated with Caro’s acid, while consecutive processing with Caro’s acid and hydrofluoric acid leads to the most prominent hydrophobization and a decrease in the surface energy.
 

Keywords: silicon, surface energy, hydrophilicity, Caro’s acid, hydrofluoric acid, hydrogen peroxide

Author affiliations:

Institute for Analytical Instrumentation of RAS, Saint Petersburg, Russia

 
Contacts: Shmykov Aleksey Yur'evich, shmykov.alexey@gmail.com
Article received by the editorial office on 25.08.2022

Full text (In Russ./In Eng.) >>

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  8. Shcheglov A.A., Shmykov A.Yu., Maltsev V.G. [Purposeful regulation of electroosmotic flow in chemically modified fused-silica capillaries for optimization of capillary electrophoresis of proteins]. Nauchnoe Priborostroenie [Scientific Instrumentation], 2003, vol. 13, no. 4, pp. 22—27.
    URL: http://iairas.ru/mag/2003/abst4.php#abst2 (In Russ.)
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  13. Shmykov A.Ju., Mjakin S.V., Bubis N.A., Kuznetsov L.M., Esikova N.A., Kurochkin V.E. [Optimization of methods for preparing the surface of channels of microfluidic chips made of borosilicate glass]. Fizika i himia stekla [Physics and Chemistry of Glass], 2020, vol. 46, no. 5, pp. 490—496. DOI: 10.31857/S013266512005011X (In Russ.)
  14. Krasovskii A.N., Myakin S.V., Osmolovskaya N.A., Pak V.G., Sychev M.M., Shmykov A.Yu. Opredelenie kraevykh uglov smachivaniya i poverkhnostnoi ehnergii polimernykh plenok i kompozitov (metodicheskie ukazaniya) [Determination of edge angles of wetting and surface energy of polymer films and com-posites (guidelines)]. Saint Petrsburg, SPbGTI (TU) Publ., 2015. 16 p. (In Russ.)
  15. Krasovsky A.N., Shmykov A.Ju., Filippov V.N., Vasiljeva I.V., Mjakin S.V., Osmolovskaya N.A., Borisova S.V., Kurochkin V.E. [Study of the surface properties of coatings comprising a mixture of polystyrene and poly(styrenesulfonic acid) on the fused silica glass]. Nauchnoe Priborostroenie [Scientific Instrumentation], 2009, vol. 19, no. 4, pp. 51—58. URL: http://iairas.ru/mag/2009/abst4.php#abst6 (In Russ.)
  16. Krasovskii A.N., Shmykov A.Yu., Osmolovskaya N.A., Mjakin S.V., Kurochkin V.E. [IR spectra and surface structure of polystyrene and polystyrene sulfonic acid coatings on fused silica glass]. Nauchnoe Priborostroenie [Scientific Instrumentation], 2014, vol. 24, no. 2, pp. 5—15. URL: http://iairas.ru/mag/2014/abst2.php#abst1 (In Russ.)
 

D. A. Belov, Yu. V. Belov, A. N. Zubik, V. E. Kurochkin

INCREASING THE DNA MELTING METHOD VALIDITY BY RE-ANALYSIS IMPLEMENTATION

"Nauchnoe Priborostroenie", 2022, vol. 32, no. 4, pp. 11—19.
doi: 10.18358/np-32-4-i1119
 

The article explores the possibility of using repeated analyses based on the DNA melting method to increase their validity, namely, to reduce the error in determining the DNA melting temperature Tm. A statistically significant difference in the Tm values of the analyzed samples in successive analyses was experimentally revealed, which prevents the validity increase. It is shown that an increase in the temperature Tm on average by 0.12 deg. in the series of experiments is due to the evaporation of 1.65% of water from the test tube. A change in mass by 0.8 ± 0.1% of the total mass of water in test tubes was experimentally revealed as a result of a thermal regime similar to the analysis by the melting method, which partially confirms the assumption. It is recommended to take into account this effect during re-analyses using the DNA melting method and to implement measures that prevent water evaporation. Analytical expressions are given for the relative assessment of the sodium ion concentration changes and the water volume in the sample.
 

Keywords: DNA melting, HRMA, evaporation

Author affiliation:

Institute for Analytical Instrumentation of RAS, Saint Petersburg , Russia

 
Contacts: Belov Dmitriy Anatol'evich, onoff_10@mail.ru
Article received by the editorial office on 30.09.2022

Full text (In Russ./In Eng.) >>

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L. E. Ermakova1, B. P. Sharfarets2, S. P. Dmitriev2, V. E. Kurochkin2

IMPLEMENTATION OF AN ACOUSTO-ELECTRIC CONVERTER.
1. DEPENDENCE OF ELECTROKINETIC PHENOMENA ON THE STRUCTURE
OF MEMBRANE MATERIALS IN AQUEOUS ELECTROLYTE SOLUTIONS

"Nauchnoe Priborostroenie", 2022, vol. 32, no. 4, pp. 20—34.
doi: 10.18358/np-32-4-i2034
 

The features of the flow potential in the electrolyte which are significant for implementing a liquid acousto-electric converter are presented. The electrochemistry of the flow potential in electrolytes is considered. The peculiarity of the process in the electrolyte solutions associated with the influence of the ionic strength of the electrolyte and its dependence on the electrokinetic radius are noted. It is shown that at small values of the electrokinetic radius, the effect of overlapping of the electric double layer occurs, leading to a sharp decrease in the absolute values of the flow potential and, consequently, to the practical impossibility of implementing the acoustoelectric transformation. The results obtained can find wide practical application.
 

Keywords: flow potential, zeta potential, electrokinetic radius, electric double layer, electric double layers overlap, sensitivity of acoustoelectric, transformation of electrokinetic effects

Author affiliations:

1Institute of Chemistry of Saint Petersburg State University, Petergof, Russia
2Institute for Analytical Instrumentation of RAS, Saint Petersburg, Russia

 
Contacts: Sharfarets Boris Pinkusovich, sharb@mail.ru
Article received by the editorial office on 24.09.2022

Full text (In Russ./In Eng.) >>

REFERENCES

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  3. Sharfarets B.P., Dmitriev S.P., Kurochkin V.E., Legusha F.F. [Acoustoelectric transducer based on electrokinetic phenomenon flow potential]. Pis'ma v ZhTF [Technical Physics Letters], 2021, vol. 47, no. 24, pp. 24—26. DOI: 10.21883/PJTF.2021.24.51794.18970 (In Russ.).
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O. A. Mirgorodskaya1, A. V. Protasov1, Yu. P. Kozmin2, R. A. Bublyaev3, J. Gobom4

FEATURES OF MASS SPECTROMETRIC DETECTION BETA AMYLOID PEPTIDES (ALZHEIMER'S PEPTIDES)

"Nauchnoe Priborostroenie", 2022, vol. 32, no. 4, pp. 35—48.
doi: 10.18358/np-32-4-i3548
 

Mass spectrometry combined with the use of isotope-labeled standards is one of the favored methods for quantitative measurement of beta-amyloid concentrations in biological media. This article is devoted to the prevention of typical systematic errors in such measurements arising from the neglect of the possibility of beta-amyloid transformation into the denatured form, which gives in mass spectra signals three times more intense than the native form. The degree of this denaturation was determined by the ability of the native form to set up
a complex with α-2-macroglobulin. The denaturing form lacks this point. It was shown that denaturation can occur in the case of heat treating in an acidic environment or when DMSO is used as a solvent. Measurement error occurs when the isotope-labeled standard and the analyte are of different forms. There are suggested recommendations to overcome systematic errors in the quantitative analysis of these compounds by forcing denaturation of the mixture of the analyte with the standard before analysis.
 

Keywords: quantitative mass spectrometry, beta-amyloids, α-2-macroglobulin

Author affiliations:

1Smorodintsev Research Institute of Influenza of Ministry of Health of the Russian Federation,
Saint Petersburg, Russia
2Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia
3Institute for Analytical Instrumentation of RAS, Saint Petersburg, Russia
4University of Gothenburg, Göteborg, Vaestra Goetaland, Sweden

 
Contacts: Bublyaev Rostislav Anatol'evich, bub-slava@yandex.ru
Article received by the editorial office on 27.08.2022

Full text (In Russ./In Eng.) >>

REFERENCES

  1. Laurents D.V., Pantoja-Uceda D., Lopez C., Carrodeguas A., Mompean M., Jimenez M.A., Sancho J. DMSO affects Aβ(1—40)' s conformation and interactions with aggregation inhibitors as revealed by NMR. Rsc Advances, 2015, vol. 5, is. 85, pp. 69761—69764. DOI: 10.1039/C5RA12100K
  2. Protasov A.V., Mirgorodskaya O.A., Kozmin Y.P., Gobom J. A mass spectrometric approach to study the interaction of amyloid β peptides with human α-2-macroglobulin. Biochimie, 2021, vol. 191, pp. 62—68. DOI: 10.1016/j.biochi.2021.08.008
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E. V. Gubina1, A. G. Kuzmin2, Yu. A. Titov2, A. A. Cherednikova2,
M. M. Guzenko2, A. Yu. Zaitceva2

EXPLORING THE POSSIBILITY OF INTELLIGENT QUALITY CONTROL OF FERMENTED
DAIRY PRODUCTS USING A GAS QUADRUPOLE MASS SPECTROMETER

"Nauchnoe Priborostroenie", 2022, vol. 32, no. 4, pp. 49—57.
doi: 10.18358/np-32-4-i4957
 

The aim of the research was to create a hardware-software method for quality control of fermented dairy products with the ability to determine the degree of compliance with a given reference standard. A real-time mass spectrometric analysis of the gas composition of three groups of farm and industrial fermented dairy product samples was performed. Group 1 consisted of yoghurts from individual farms made of cow's and goat's milk. Group 2 consisted of samples of other fermented products from individual farms (kefir, yoghurt, sour cream). Group 3 consisted of samples of industrial yoghurts made of cow's milk. A total of nineteen samples of fermented dairy products were analysed. Analysis of sample composition was performed on a small-sized quadrupole mass spectrometer MS7-200 with direct sample introduction at atmospheric pressure. Samples were taken into specially prepared medical syringes of 20 ml capacity. The use of statistical analysis methods enables the assignment of groups of samples with similar properties and the classification of production as industrial or piece production. Mass-spectrometric techniques using multivariate data analysis methods have been shown to be promising as universal technologies for the analysis of foodstuffs.
 

Keywords: mass spectrometric analysis, food industry, dairy products, principal component method

Author affiliations:

1Peter the Great St. Petersburg Polytechnic University, Saint Petersburg, Russia
2Institute for Analytical Instrumentation of RAS, Saint Petersburg, Russia

 
Contacts: Gubina Evgeniya Vyacheslavovna, gubina.z@yandex.ru
Article received by the editorial office on 05.08.2022

Full text (In Russ./In Eng.) >>

REFERENCES

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  6. Manoilov V.V., Novikov L.V., Zarutskii I.V., Kuzmin A.G., Titov Y.A. Methods for processing mass spectrometry signals from exhaled gases for medical diagnosis . Biomedical engineering , 2020, vol. 53, no. 5, pp. 355—359. DOI:  10.1007/s10527-020-09942-0
  7. Manoilov V.V., Kuzmin A.G., Titov U.A. Extraction of information attributes from the mass spectrometric signals of air. Journal of Analytical Chemistry , 2016, vol. 71, no. 14, pp. 1301—1308. DOI: 10.1134/S1061934816140094
  8. Manoilov V.V., Kuzmin A.G., Zarutskii I.V., Titov U.A. Samsonova N.S. [Methods of processing and investigation of the possibilities of classification of mass spectra of exhaled gases]. Nauchnoe Priborostroenie [Scientific Instrumentation], 2019, vol. 29, no. 1, pp. 106—111.
    DOI: 10.18358/np-29-1-i106110 (In Russ.).
  9. Mazing M.S., Zaitceva A.Y., Kislyakov Y.Y., Davydov V.V., Kondakov N.S., Avdyushenko S.A. Analytical complex for study of the oxygen status of tissues of the human organism. Journal of Physics: Conference Series. IOP Publishing, 2020, vol. 1695, Id. 012065.
    DOI: 10.1088/1742-6596/1695/1/012065
  10. Mazing M.S., Zaitceva A.Y., Kislyakov Y.J. Development of a method for assessing of the oxygen supply of tissues based on a multi-channel spectrum analyzer. International Youth Conference on Electronics, Telecommunications and Information Technologies. Springer, Cham., 2020, pp. 233—239. DOI: 10.1007/978-3-030-58868-7_26
 

M. M. Guzenko, A. Yu. Zaitceva

INTELLIGENT ION COMPOSITION SENSOR RANKING SYSTEM BREAST MILK

"Nauchnoe Priborostroenie", 2022, vol. 32, no. 4, pp. 58—67.
doi: 10.18358/np-32-4-i5867
 

An intelligent sensor system has been developed and investigated that allows qualitative medical ranking of breast milk and dairy products. Electrochemical sensors with sensitivity to the principal significant components of the biological medium under study were used. It was found that the 'digital images' of the breast milk of women who had undergone disease differed significantly from those of healthy women. The principal component method has been applied to rank breast milk and cow's milk, and groups of biological media similar in their properties have been identified. Analyzing the results of the studies, it is possible to state the effectiveness of the developed method for biomedical research.
 

Keywords: breast milk, ranking system, sensor system, principal component method, electrochemical sensors

Author affiliations:

Institute for Analytical Instrumentation of RAS, Saint Petersburg, Russia

 
Contacts: Zaitceva Anna Yurievna, anna@da-24.ru
Article received by the editorial office on 24.09.2022

Full text (In Russ./In Eng.) >>

REFERENCES

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M. V. Zhukov, S. Yu. Lukashenko, I. D. Sapozhnikov, M. L. Felshtyn,
O. M. Gorbenko, S. V. Pichakhchi, A. O. Golubok

MULTIMODE SCANNING ION CONDUCTION MICROSCOPE
WITH PIEZO-INERTIAL MOVING SYSTEM

"Nauchnoe Priborostroenie", 2022, vol. 32, no. 4, pp. 68—87.
doi: 10.18358/np-32-4-i6887
 

A scanning ion conductivity microscope (IDS) has been developed, operating in several modes: DC mode, current modulation mode and hopping mode. It is built with a piezoinertial movement system, nanosonds in the form of glass nanopipettes have been created and tested with an internal radius of r ~ 50 nm. Volt-ampere characteristics I (V) and current dependence on the distance between the probe and the sample I (z) (input/output curves) were measured. Images of a polymer test object with a periodic structure and a biological object (CHO cell) were obtained, their quality was assessed, the features of the SMIP operation in various modes are discussed. Multimode SMIP provides non-destructive non-contact visualization of soft objects in a liquid conducting medium with nanometer spatial resolution in various measuring modes and can be used in biology, cytology, electrochemistry and medicine when studying inorganic soft objects, biological objects in buffer media, etc.
 

Keywords: nanopipette, probe, electrode, ion conductivity, scanning probe microscopy,
scanning ion-conductance microscope

Author affiliations:

Institute for Analytical Instrumentation of RAS, Saint Petersburg, Russia

 
Contacts: Zhukov Mikhail Valeryevich, cloudjyk@yandex.ru
Article received by the editorial office on 03.10.2022

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K. I. Sukhachev, K. E. Voronov, A. S. Dorofeev, D. A. Shestakov, A. A. Artyushin

DEVELOPMENT OF A HIGH-PERFORMANCE COMPUTING SYSTEM
BASED ON AN IP-CORE FOR SPACE SCIENTIFIC EQUIPMENT

"Nauchnoe Priborostroenie", 2022, vol. 32, no. 4, pp. 88—106.
doi: 10.18358/np-32-4-i88106
 

The article presents the result of the development and implementation of a universal synthesized processor core based on integrated circuits FPGAs of domestic and foreign production. The possibility of creating a high-performance computing system based on FPGA is shown. The description of the structure of the system, the main processor core and associated modules is given. The system of processor commands is presented. The process of developing a program for a synthesized controller and a variant of implementing a control system based on the developed controller are presented.
 

Keywords: FPGA, IP processor core, microcontrollers, onboard control systems

Author affiliations:

Samara National Research University, Samara, Russian Federation

 
Contacts: Artyushin Andrey Alekseevich, artyushin.aa@ssau.ru
Article received by the editorial office on 01.09.2022

Full text (In Russ./In Eng.) >>

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N. O. Borshchev

PARAMETRIC IDENTIFICATION OF THE THERMAL
CONDUCTIVITY COEFFICIENT OF MIRROR MATERIALS
OPERATING IN THE ORBITAL FLIGHT SECTION

"Nauchnoe Priborostroenie", 2022, vol. 32, no. 4, pp. 107—123.
doi: 10.18358/np-32-4-i107123
 

This paper presents a method for determining the thermal conductivity coefficient of mirror materials of spacecraft operating in the orbital flight section. This problem is solved as a problem of searching for the global extremum of the parametrized coefficient of thermal conductivity in the course of minimizing the root-mean-square functional of the discrepancy between the theoretical and experimental temperature fields in the places where temperature sensors are installed. Inverse problems are considered incorrect due to "noisy" input data. To overcome this, it is necessary to apply regularization. This study employs the iterative regularization method, with the iteration number serving as the regularized parameter. The method of conjugate gradients is chosen as the optimization algorithm, as the most accurate method of the first order of convergence.
 

Keywords: inverse heat conduction problem, iterative regularization method, root-mean-square error, temperature field, spacecraft

Author affiliations:

Astrocosmic Center of the Federal State Institution of Science S.A. Lebedev Institute, Moscow, Russia

 
Contacts: Borshchev Nikita Olegovich, www.moriarty93@mail.ru
Article received by the editorial office on 05.08.2022

Full text (In Russ./In Eng.) >>

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S. V. Vantsov, F. V. Vasiliev, O. V. Khomutskaya, M. A. Korobkov

MANUFACTURING PROCESS CONTROL TASKS

"Nauchnoe Priborostroenie", 2022, vol. 32, no. 4, pp. 124—137.
doi: 10.18358/np-32-4-i124137
 

Obtaining a quality end product is the goal of any manufacturing process control. In the formal description of control problems, this goal allows us to form the boundary conditions for solving the control task. An additional condition for choosing a solution is to ensure the reliability of the process. The starting conditions for solving the control problem are the components of the vector of initial state parameters, determined by the degree of adjustment of the initial parameters and process modes. Understanding the initial and boundary conditions of existence allows us to formulate a generalized formal problem of process control, which consists in finding a vector of control variables that provide a minimum of error, taking into account the influence of a vector of random external variables. The problem is solved by the method of successive approximations. The stages of primary and secondary optimization in the construction of control algorithms are considered. The possibility of reducing the complexity of control tasks is shown by refusing to control individual components of the state vector and transforming control to ensure a minimum of the generalized error measure. In this formulation, the problem of process control can be reduced to the problem of process regulation. A process control scheme is presented. It considers the separability of error minimization for each component of the state vector. The assertions are illustrated by the example of the problem of managing a digital production site for performing the technological operation of etching printed circuit boards. This operation most fully reflects the initial provisions on the continuity of the procedures performed during its implementation and the degradation of the original state vector.
 

Keywords: manufacturing process, reliability, digitalization of production, control systems, printed circuit boards, printed circuit board etching, manufacturing, industry 4.0

Author affiliations:

Moscow Aviation Institute (National Research University), Russia

 
Contacts: Khomutskaya Ol'ga Vladislavovna, khomutskayaov@gmail.com
Article received by the editorial office on 22.09.2022

Full text (In Russ./In Eng.) >>

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    DOI: 10.3103/S1068798X20050202
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  16. Markin S. [How to poison boards?]. Khimiya i zhizn' [Chemistry and Life], 1990, no. 7, pp. 76—77. URL: ftp://nozdr.ru/biblio/j/hj/1990/ (In Russ.).
  17. Dzyubanenko A.A. [Implementation of M2M on the process line of automatic installation of printed circuit boards in conditions of digitalization of production]. Cbornik materialov V Mezhdunarodnoi nauchno-prakticheskoi konferentsii [Proc. of V international scientific and practical conference], Makhachkala, 2021, pp. 104—107. (In Russ.). URL: https://www.elibrary.ru/item.asp?id=46415984
 

ISSN 0868–5886      NAUCHNOE PRIBOROSTROENIE, 2022, Vol. 32, No. 4, pp. 138–143

CONTENTS OF VOLUME 32

doi: 10.18358/np-32-4-i138143


 NUMBER 1
 SYSTEM ANALYSIS OF MEASURING DEVICES AND METHODS (pp. 3–20)
 PHYSICS OF INSTRUMENT MAKING (pp. 21–67)
 MATHEMATICAL METHODS AND MODELLING IN INSTRUMENT MAKING (pp. 68–92)
 
 NUMBER 2
 INSTRUMENT MAKING FOR BIOLOGY AND MEDICINE (pp. 3–32)
 PHYSICS OF INSTRUMENT MAKING (pp. 33–83)
 
 NUMBER 3
 REVIEWS (pp. 3–58)
 MATHEMATICAL METHODS AND MODELLING IN INSTRUMENT MAKING (pp. 59–128)
 
 NUMBER 4
 PHYSICS AND CHEMISTRY OF INSTRUMENT MAKING (pp. 3–34)
 INSTRUMENT MAKING FOR BIOLOGY AND MEDICINE (pp. 35–67)
 DEVELOPMENT OF MEASURING DEVICES AND SYSTEMS (pp. 68–106)
 MATHEMATICAL METHODS AND MODELLING IN INSTRUMENT MAKING (pp. 107–137)
 Contents of volume 32 (pp. 138–143)
 
 Contents of volume 32 (pp. 138–143)
 The authors index of volume 32 (p. 144)

Full text (In Russ./In Eng.) >>
 

THE AUTHORS INDEX OF VOLUME 32

"Nauchnoe Priborostroenie", 2022, vol. 32, no. 4, p. 144.
doi: 10.18358/np-32-4-i144144
 

Full text (In Russ.) >>

Ulitsa Ivana Chernykh, 31-33, lit. A, St. Petersburg, Russia, 198095, P.O.B. 140
tel: (812) 3630719, fax: (812) 3630720, mail: iap@ianin.spb.su

content: Valery D. Belenkov design: Banu S. Kuspanova layout: Anton V. Manoilov