V. A. Kazakov*, M. N. Slyadnev*, A. A. Sidorova,
A. A. Kartsova, A. A. Ganeev*, L. N. Moskvin
St.Petersburg State University
*Lumex Ltd. & St.Petersburg State University
This paper deals with optimization
of analytical processes in a hyphenated system of capillary electrophoresis
-- quadrupole mass spectrometer with electrospray ionization (CE-ESI-MS)
applied to determination of catecholamines (CA). Conditions of electrophoretic
separation and electrospray ionization of model CA mixtures were studied.
Optimal buffer composition for CE separation and ESI-MS detection conditions
were obtained both for the electrospray chamber and mass analyzer. Determination
of CA using the model mixture under optimal analytical conditions the was
demonstrated.