SINGLE  MOLECULE  DETECTION  IN  LIQUID.
ANALYSIS  OF  SAMPLES  BELOW  1*10**(-15) M.
HIGH-PERFORMANCE  CAPILLARY  ELECTROPHORESIS
WITH  SINGLE-MOLECULAR  LIF  DETECTION
 

B. G. Belenkii, R. A. Kozulin, V. E. Kurochkin

Institute for Analytical Instrumentation RAS, Saint-Petersburg


  Methods and criteria of single-molecular detection in liquid are considered. Particular attention is given to detection of single molecules in capillary electrophoresis by the laser-induced fluorescence technique. The main experimental difficulties encountered in this field are stressed.